Table 3.

Histomorphometry of bones from WT and OPN−/− mice

Tibial histomorphometry	WT	OPN−/−
Cancellous bone area (%)	16.2 ± 2.7	29.3 ± 5.3a
Trabecular spacing (μm)	195 ± 38.2	98.9 ± 7.6b
Trabecular number (No./mm)	4.79 ± 0.66	6.58 ± 0.44b
Trabecular thickness (μm)	28.1 ± 3.61	55.1 ± 4.68c
Number of osteoclasts (n)	76 ± 9.7	97 ± 2.2b
Osteoclasts/tissue area (No./mm2)	134 ± 17	149 ± 12
Eroded perimeter (%)	4.56 ± 0.85	1.74 ± 0.69a
Mineral apposition rate (μm2/μm/day)	1.50 ± 0.33	1.31 ± 0.14
Bone formation rate/bpm (μm2/μm/day)	0.60 ± 0.17	0.54 ± 0.10

Longitudinal sections of the decalcified tibia were made. The sections were stained and the histomorphometric measurements were performed as described in MATERIALS AND METHODS. Data shown are means ± SE. There are 4 to 5 animals per group. 

^a p < 0.05; 

^b p < 0.02; 

^c p < 0.002.