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. 1974 Jun;1(3):223–227. doi: 10.1111/j.1365-2125.1974.tb00240.x

The effects of salbutamol and terbutaline on physiological tremor, bronchial tone and heart rate

Judith M Watson, A Richens
PMCID: PMC1402544  PMID: 22454951

Abstract

1 The effects of oral doses of the bronchodilator drugs, salbutamol (4 and 8 mg) and terbutaline (5 and 10 mg), on physiological tremor, bronchial tone, heart rate and blood pressure were studied in six normal subjects.

2 Both drugs produced a significant increase in physiological tremor, compared with placebo. Terbutaline, but not salbutamol, produced a dose related response. No significant differences were observed between drugs.

3 Terbutaline (5 and 10 mg) and salbutamol (8 mg) produced a significant bronchodilatation compared with placebo. Dose related responses were obtained with both drugs, although this reached significance only with terbutaline.

4 Both doses of each drug produced a tachycardia, although this was only statistically significant with the high doses.

5 No significant change in blood pressure was observed with either drug.

6 Peak effects of salbutamol occurred between 1 and 3 h and terbutaline between 1 and 4 hours. Both drugs were still active at 6 hours.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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