Abstract
Salbutamol (8 mg) was administered twice daily as a sustained release formulation to twenty-four asthmatic patients for up to four weeks under double-blind conditions. 2. The ability of bronchial smooth muscle to respond was determined by monitoring the response to salbutamol (200 mug) administered by aerosol at set intervals three times a week. 3. There was no evidence of diminishing response during the study period. 4. It is concluded that tolerance to salbutamol does not occur at therapeutic dose levels and that clinical observations of tolerance may be due to other factors.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Choo-Kang Y. F., Simpson W. T., Grant I. W. Controlled comparison of the bronchodilator effects of three beta-adrenergic stimulant drugs administered by inhalation to patients with asthma. Br Med J. 1969 May 3;2(5652):287–289. doi: 10.1136/bmj.2.5652.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Conolly M. E., Davies D. S., Dollery C. T., George C. F. Resistance to -adrenoceptor stimulants (a possible explanation for the rise in ashtma deaths). Br J Pharmacol. 1971 Oct;43(2):389–402. [PMC free article] [PubMed] [Google Scholar]
- Cooke N. J., Kerr J. A., Willey R. F., Hoare M. V., Grant I. W., Cromptom G. K. Response to rimiterol and salbutamol aerosols administered by intermittent positive-pressure ventilation. Br Med J. 1974 May 4;2(5913):250–252. doi: 10.1136/bmj.2.5913.250. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Griffin J. P., Kamburoff P. L., Prime F. J., Arbab A. G. Thymoxamine and airways obstruction. Lancet. 1972 Jun 10;1(7763):1288–1288. doi: 10.1016/s0140-6736(72)91011-2. [DOI] [PubMed] [Google Scholar]
- HUME K. M., GANDEVIA B. Forced expiratory volume before and after isoprenaline. Thorax. 1957 Sep;12(3):276–278. doi: 10.1136/thx.12.3.276. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Parker S. S., Choo-Kang Y. F., Cooper E. J., Cameron S. J., Grant I. W. Bronchodilator effect of oral salbutamol in asthmatics treated with corticosteroids. Br Med J. 1971 Oct 16;4(5780):139–142. doi: 10.1136/bmj.4.5780.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith R. N., Davies H. J. Long-term use of a salbutamol inhaler in general practice. Practitioner. 1973 Mar;210(257):425–428. [PubMed] [Google Scholar]
- Svedmyr N., Larsson S., Thiringer G. Letter: Studies of resistance to long-acting adrenergic beta-stimulators in asthmatic patients. Br Med J. 1974 Jun 22;2(5920):668–669. doi: 10.1136/bmj.2.5920.668-c. [DOI] [PMC free article] [PubMed] [Google Scholar]