FIGURE 1.

Simulated system of SecYEβ in a lipid bilayer/water environment. SecYEβ is shown in cartoon representation with SecY, SecE, and Secβ colored in gray, orange, and ochre, respectively. The plug, transmembrane domain 2a of SecY (residues Ile⁵⁵ to Gly⁶⁵) is presented in red, and TM2b (residues Gly⁷⁶ to Ser⁹¹) and TM7 (residues Asn²⁵⁶ to Gly²⁸⁰) are shown in green (both also of SecY). The lipids are seen in yellow licorice representation with the phosphorus, nitrogen, and an oxygen of the headgroup highlighted as spheres colored in tan, blue, and red, respectively. The water box is drawn in transparent blue surface representation. (A) Side view of the simulated system. To display the protein more clearly, some lipids and water molecules have been removed, leaving a flat outward face. (B) Top view of the simulated system. The top solvation layer has been removed.