FIGURE 6.

Sensitivity of fibroblast invasiveness to other PDGF rate constant values. Calculations were performed as in Fig. 5 after adjustments to rate constants in the PDGF balance, Eq. 7. See accompanying descriptions in the text. (a) Fibroblast penetration depth and population size at t = 10 days, normalized by the base-case values, after a 10-fold reduction or increase in the indicated parameter values. (b) Peak values in chemotactic signaling, Δm, at the leading fibroblast front and clot-dermis interface at t = 7 days were determined for the same parameter values as in a. (c and d) Fibroblast density and PDGF concentration profiles at t = 7 days for the case of a 10-fold reduction in k_u (c) or 10-fold increases in both k_s and k_v (d); these parameter shifts yield the same u_max and nearly identical u^† values.