TABLE 1.

Model parameters and order-of-magnitude, base-case values

Parameter	Definition	Base value
ɛ†	Characteristic cell dimension	0.03 mm
α	Maximum receptor/PI 3-kinase ratio	10
κ	Dimensionless KD, PI 3-kinase recruitment	0.1
m0	Dimensionless 3′ PI density, unstimulated	0.1
ks	Normalized PDGF secretion rate in the clot	1 h−1
Du	PDGF diffusion coefficient in tissue	0.01 mm2/h*
ku	Rate constant, spontaneous PDGF degradation	0.1 h−1
kv	Rate constant, fibroblast-mediated PDGF depletion	1 h−1*
μm	Rate constant, maximal fibroblast growth	0.05 h−1
γ	Dimensionless saturation constant, fibroblast growth	0.1
v*	Dimensionless, contact-inhibited fibroblast density	10
n	Contact inhibition sensitivity parameter	3
kd	Rate constant, fibroblast death	0.01 h−1
v0	Dimensionless resting cell density, clot (dermis)	1 (0)
Dv*	Maximum fibroblast dispersion coefficient	3 × 10−4 mm2/h*
Stax*†	Maximum chemotactic cell speed	0.1 mm/h*

^*The values of these parameters are discussed in Appendix C.

^†The product of these two parameters may be lumped as one in this model.