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. Author manuscript; available in PMC: 2006 Mar 17.
Published in final edited form as: Antisense Nucleic Acid Drug Dev. 2003 Feb;13(1):45–55. doi: 10.1089/108729003764097331

Figure 1.

Figure 1.

Summary of locations of hybridization-competent sites of HIV-2 leader region RNA as determined by reverse transcription with random oligonucleotide libraries (Allawi et al., 2001). The regions of RNA determined to be accessibly by RT-ROL are indicated with lines drawn on a secondary structure model of HIV-2 leader region RNA derived from biochemical data, comparative sequence analysis, and computational energy minimization (Berkhout, 1992; Berkhout and Schoneveld, 1993; Rhim and Rice, 1994). The viral RNA nucleotide numbers corresponding to the 5′ end of the oligonucleotides used in this study are indicated.