FIGURE 1.

Numerical solution of GAG accumulation in an engineered cartilage construct without growth factor variability (Model I Eq 8). The top curve (dash line) was obtained by approximating the growth rate as λ₁ = 0.0584 (estimated from the data reported by Buschmann et al.⁴) and the bottom curve (dash–dot line) has been obtained by approximating λ₁ = 0.005 (estimated from the data reported by Wilson et al.³⁶). Here k is the carrying capacity of the GAG molecules in engineered cartilage constructs (noted as K₁ in the text).