Table 3.

The NSMC and NSCS test results for BRCA1, BRCA2, and p16 genes

Class ID	Sites	Mutations	Hotspots	P(H1)/χ2
BRCA1
Synonymous	33	142	16
Non-synonymous	356	1842	170	0.204/0.006
Nonsense	141	704	74	0.079
BRCA2
Synonymous	55	103	20
Non-synonymous	797	4871	352	0.071/1.2
Nonsense	179	844	79	0.018
p16
Synonymous	40	63	13
Non-synonymous	171	321	65	0.388/0.423
Nonsense	18	162	14	0.070

The data for combined spectra from all tumor types are shown. Other designations are as in Table 1.