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Hotspots non-randomly associated with non-synonymous sites in tumor suppressor genes according to the NSB test
| Gene | Total number of codons | Number of non-synonymous hotspots |
| TP53 | 394 | 59 |
| BRCA1 | 1864 | 12 |
| BRCA2 | 3419 | 27 |
| p16 | 157 | 1 |
The hotspots are listed in Additional file 3
