TABLE 3.

In vitro susceptibilities of bloodstream Candida spp. isolates in the EIEIO program, July 1998 to June 2001

Species (no. of isolates tested)	Antifungal agent	MIC (μg/ml)a			% Resistantb
		Range	50%	90%
All Candida species (254)	Amphotericin B	0.25-2.0	1.0	1.0
	5-FC	0.06->128.0	0.12	1.0	3.6
	Fluconazole	0.12-128.0	0.25	8.0	2.8
	Itraconazole	0.007->8.0	0.06	1.0	11.0
	Posaconazole	0.007->8.0	0.03	0.5
	Ravuconazole	0.007-8.0	0.007	0.25
	Voriconazole	0.007-8.0	0.007	0.25
C albicans (148)	Amphotericin B	0.25-1.0	1.0	1.0
	5-FC	0.06->128.0	0.25	1.0	2.7
	Fluconazole	0.12-2.0	0.25	0.5	0
	Itraconazole	0.007-0.25	0.03	0.06	0
	Posaconazole	0.007-0.12	0.015	0.06
	Ravuconazole	0.007-0.06	0.007	0.015
	Voriconazole	0.007-0.25	0.007	0.015
C. glabrata (51)	Amphotericin B	0.25-1.0	1.0	1.0
	5-FC	0.06-16.0	0.12	0.12	0
	Fluconazole	1-28.0	8.0	32.0	9.8
	Itraconazole	0.06->8.0	1.0	2.0	52.9
	Posaconazole	0.06->8.0	0.5	1.0
	Ravuconazole	0.03-8.0	0.25	1.0
	Voriconazole	0.03-8.0	0.12	1.0
C. tropicalis (28)	Amphotericin B	0.5-1.0	1.0	1.0
	5-FC	0.06->128.0	0.25	16.0	7.1
	Fluconazole	0.25-2.0	0.5	2.0	0
	Itraconazole	0.015-1.0	0.12	0.25	3.6
	Posaconazole	0.015-0.25	0.06	0.12
	Ravuconazole	0.007-0.25	0.03	0.12
	Voriconazole	0.007-0.12	0.03	0.06
C. parapsilosis (17)	Amphotericin B	1.0-2.0	1.0	2.0
	5-FC	0.06-0.25	0.12	0.25	0
	Fluconazole	0.25-1.0	0.5	1.0	0
	Itraconazole	0.015-0.25	0.12	0.25	0
	Posaconazole	0.015-0.12	0.06	0.12
	Ravuconazole	0.007-0.03	0.015	0.03
	Voriconazole	0.007-0.03	0.015	0.03

^a50% and 90%, MIC₅₀ and MIC₉₀, respectively.

^bPercent resistant according to NCCLS breakpoints (10).