Table 2.
Treatment | Mean surviving fractionc ± SE | Protection ratio ± SE | P valued | |
---|---|---|---|---|
Immediatea | 2 Gy | 0.37 ± 0.02 | ||
40 μM SH-2 Gy | 0.40 ± 0.01 | 1.05 ± 0.22 | P > 0.05 | |
4 mM SH-2 Gy | 0.67 ± 0.03 | 1.81 ± 0.40 | P < 0.0001 | |
Delayedb | 2 Gy | 0.30 ± 0.03 | ||
40 μM SH-2 Gy | 0.43 ± 0.04 | 1.43 ± 0.77 | P = 0.0151 | |
4 mM SH-2 Gy | 0.44 ± 0.04 | 1.47 ± 0.72 | P = 0.0044 |
HMEC were treated with WR1065 (SH) for 30 min, irradiated, and plated for survival.
HMEC were treated with WR1065 (SH) for 30 min, washed to remove the drug, irradiated 24 h after drug treatment, and plated for survival.
Average from three separate experiments.
Comparison between cells irradiated with 2 Gy and cells treated with WR1065 (SH) and then irradiated. P values were calculated using a two-tailed t test.