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19F NMR titration of TAR RNA hairpins (II–IV) with argininamide (A), Mg2+ (B) and Co(NH3)63+ (C). Normalised chemical shift changes of FU-23 (red circles), FU-25 (magenta squares), FU-31 (green stars), FU-38 (black diamonds) and FU-40 (blue triangles) are presented. Experimental data for (A) and (B) are shown together with the best fits of a single site binding model.
