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. 2006 Mar 20;103(13):5161–5166. doi: 10.1073/pnas.0600948103

Fig. 1.

Fig. 1.

Spine density in the DG. Spine segments are shown from 2-, 4-, 12-, and 18-month-old WT littermates (A, C, E, and G, respectively) and Tg mice (B, D, F, and H, respectively). Segments are from the molecular layer of the DG (middle and outer molecular layers combined). (Scale bar, 10 μm.) (I) Spine deficits were detected in 4-, 12-, and 18-month-old Tg mice compared with WT littermates but not in 2-month-old Tg mice (∗, P < 0.05). Also shown is a reduced spine density detected over time in Tg mice and WT littermates (†, P < 0.05; see Results for specific comparisons).