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Age-associated impairment in CFC. Tg mice display intact contextual memory at 2 months of age. A significant impairment in hippocampal-dependent conditioning is observed with lower levels of freezing to context at 5-month-old Tg mice when compared with younger ages (∗, P < 0.05) with a trend toward an impairment in the 4-month-old group (†, P = 0.05). No differences were observed in freezing to context in the WT animals across all ages examined.
