Table 1.
LEDGF/p75 mutants
| Mutant name | Targeted region(s)a | Mutations |
|---|---|---|
| MutL1 | NLS, AT1, AT2 | R146S, R147A, R149A, K150A, R151S, K152A, R180A, G181A, R182A, R194A, G195A, R196A |
| MutL2 | NLS | R146S, R147A, R149A, K150A, R151S, K152A |
| MutL3 | AT1, AT2 | R180A, G181A, R182A, R194A, G195A, R196A |
| MutL4 | AT1 | R180A, G181A, R182A |
| MutL5 | AT2 | R194A, G195A, R196A |
| MutL6 | NLS, AT1, AT2, IBD | R146S, R147A, R149A, K150A, R151S, K152A, R180A, G181A, R182A, R194A, G195A, R196A, D366N |
| MutL7 | PWWP | Δ1-92 |
| MutL8 | PWWP, NLS, AT1, AT2 | Δ1-92, R146S, R147A, R149A, K150A, R151S, K152A, R180A, G181A, R182A, R194A, G195A, R196A |
| MutL9 | PWWP, AT1, AT2 | Δ1-92, R180A, G181A, R182A, R194A, G195A, R196A |
aNLS, nuclear localization signal (residues 146–152); AT1, AT-hook motif 1 (residues 178–183); AT2, AT-hook motif 2 (residues 191–197); PWWP, PWWP domain (residues 1–93); IBD, integrase-binding domain (residues 347–429) (15).