TABLE 5.

Structures of carbohydrates and rNV VLP binding

Symbol	Structurea,b	Name	Expression	rNV VLP bindingc
Glc	Glc-R	Glucose	—d (control)	0
H	Fucα-1,2-Galβ-R	H disaccharide	RBC + gut	(+)
Lec	Galβ-1,3-GlcNAcβ-R	Type 1 precursor	—	0
Lac	Galβ-1,4-Glcβ-R	Lactose	—	0
H type 2	Fucα-1,2-Galβ-1,4-GlcNAcβ-R	H type 2	RBC + gut	++
Lea	Galβ-1,3-(Fucα-1,4-)GlcNAcβ-R	Lea	Gut	0
Lex	Galβ-1,4-(Fucα-1,3-)GlcNAcβ-R	Lex	Gut	0
Led	Fucα-1,2-Galβ-1,3-GlcNAcβ-R	Led, H type 1	Gut	++++
Leb	Fucα-1,2-Galβ-1,3-(Fucα-1,4-)GlcNAcβ-R	Leb	Gut	+++
Ley	Fucα-1,2-Galβ-1,4-(Fucα-1,3-)GlcNAcβ-R	Ley	Gut	+
H type 3	Fucα-1,2-Galβ-1,3-GalNAcβ-R	H type 3	RBC + gut	Not tested

^aReviewed in references 29 and 31. Type 1 precursor has β-1,3 linkage, found in Le^a, Le^d, and Le^b; type 2 precursor has β-1,4 linkage, found in H type 2, Le^x, and Le^y.

^bGlc, glucose; R, polyacrylamide with or without biotin (-PAA-biotin or -PAA, respectively); Fuc, fucose; Gal, galactose; GlcNAc, N-acetylglucosamine; Lac, lactose; GalNAc, N-acetylgalactosamine.

^c0, no binding; (+), weak binding; + to ++++, lower to higher strength of binding.

^d—, not a terminal moiety.