TABLE 2.

Expression of genes in the Ras and Notch pathways

Gene	Fold changea
	BM	Spleen
Ras-associated genes
Ki-Ras	−1.5 ± 0.1	2.7 ± 0.2
PAC-1 ERK/MAPK phosphataseb	−2.3 ± 0.1	−2.2 ± 0.2
Kinase suppressor of Ras (KSR1)b	2.5 ± 0.3	−2.5 ± 0.2
Rho A GTPase	−2.8 ± 0.3	−1.1 ± 0.2
Rho B GTPase	−2.4 ± 0.3	2.4 ± 0.2
Raf	−5.2 ± 0.5	−1.0 ± 0.3
GBP-2 GTPase	−3.3 ± 0.3	3.4 ± 0.2
SOS-2	−2.7 ± 0.3	1.3 ± 0.2
Vav	−2.8 ± 0.3	1.7 ± 0.2
DAB-2	−3.2 ± 0.3	1.0 ± 0.2
ERK-1	−2.2 ± 0.2	−1.2 ± 0.2
ERK-5	−5.6 ± 0.3	1.7 ± 0.5
MEK-5	−3.3 ± 0.2	−1.3 ± 0.1
Notch-associated genes
Delta (Dlk1-like)	2.7 ± 0.2	−2.3 ± 0.2
Enhancer of Split (mESG)	2.2 ± 1.0	−1.2 ± 0.2
Suppressor of Hairless (RBP-L)	1.4 ± 0.2	2.3 ± 0.3
Sel 11 inhibitor of Notchb	−3.0 ± 0.2	4.2 ± 0.1

^aIdentical microarray experiments were performed in duplicate with CD19⁺ bone marrow (BM) and splenic B cells from wild-type and LMP2A transgenic mice. The average fold change in gene expression in cells from LMP2A transgenic mice versus wild-type mice from the two experiments is shown, along with the standard deviation. Negative values indicate decreased expression.

^bShown to be a positive or negative regulator, depending on the model system.