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Model of the mechanism of neutralization by CD4BS antibodies. Free gp120 may sample multiple conformations but is locked into the CD4-bound conformation by CD4 (17). This gp120 conformation is competent for chemokine receptor binding and virus entry. Because CD4BS antibodies prefer to bind other conformations of gp120 (33), they prevent gp120 from assuming the CD4-bound conformation and from binding the chemokine receptor.
