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SIR2α is present at high level in proliferating granulosa cells. Ovaries from wild-type mice were sectioned and stained with antibody to SIR2α (panel A) and with Hoechst 33258 (panel B). The merged image is shown in panel C. The box in panel C was used to deconvolve the image, and the result is shown in panels D to F. Note that the SIR2α protein is nuclear but appears to be excluded from the nucleolus and those regions of the nucleus that stain intensely with Hoechst dye.
