Fig. 1. (A) Coiled-coil probability for several 6TM1P ion channels. (B) Alignments of the amino acid sequences of TCC domains from different gene families. The domains corresponding to the KCNQ channels as well as the SK calcium channels, TRP2 and TRPC7 are bipartite [see (A) and text]. The first letter of the abbreviated names indicates the species [human (h), rat (r), or mouse (m)] and numbering refers to the position of the last depicted residue. Heptad positions a and d are emphasized (black boxes). Putative non-helical stretches are underlined.