Fig. 7. The DE-loop in different ATPases showing the different interactions with effectors. The sequences aligned in Figure 6G are coloured in black. (A) Escherichia coli MutS dimer binding to mismatch DNA (coloured in dark grey), with the DE-loop contacting the other ATPase domain. (B) Top view from the bovine F1-ATPase, with the DE-loop in contact with the central stalk (γ-subunit) (also coloured in black). (C) Bacteriophage T7 gp4 helicase, and (D) E.coli RepA helicase in which the DE-loop is thought to contact a centrally located DNA.