Skip to main content
PMC home page
Journal of Psychiatry & Neuroscience : JPN logoLink to Journal of Psychiatry & Neuroscience : JPN
. 2001 May;26(3):235–246.

Novelty-elicited mismatch negativity in patients with schizophrenia on admission and discharge.

I Grzella 1, B W Müller 1, R D Oades 1, S Bender 1, U Schall 1, D Zerbin 1, J Wolstein 1, G Sartory 1
PMCID: PMC1408303  PMID: 11394193

Abstract

OBJECTIVE: Given recent reports of differences between mismatch negativity (MMN) elicited by always novel sounds (novelty-elicited MMN) and that elicited by repeated rare deviants (conventional MMN), we investigated novelty-elicited MMN and P3a in patients with schizophrenia before and after a nonstandardized inpatient treatment. DESIGN: Electrophysiological and clinical assessment of patients on admission and discharge from hospital. Assessment of control subjects on 2 sessions. SETTING: Inpatient treatment in a psychiatric university hospital. SUBJECTS: 20 patients with schizophrenia and 21 healthy control subjects of similar age and sex. Selection of patients with first- to third-episode schizophrenia. OUTCOME MEASURES: Early and late component MMN amplitudes and latencies, P3a amplitudes and latencies, Positive and Negative Syndrome Scale (PANSS), Global Assessment of Functioning (GAF), Extrapyramidal Symptom Scale (EPS), Abnormal Involuntary Movement Scale (AIMS) and chlorpromazine equivalents. RESULTS: In patients with schizophrenia, novelty-elicited MMN was unimpaired on admission, and there was a statistically significant reduction of the late MMN component with treatment. Improvements in symptom expression were associated with increased latencies of the early MMN component. CONCLUSION: Results indicate differences in information processing between conventional and novelty-elicited MMN. Some components of the novelty-elicited MMN might be more state dependent than those of the conventional MMN.

Full text

PDF
245

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alain C., Hargrave R., Woods D. L. Processing of auditory stimuli during visual attention in patients with schizophrenia. Biol Psychiatry. 1998 Dec 1;44(11):1151–1159. doi: 10.1016/s0006-3223(97)00478-2. [DOI] [PubMed] [Google Scholar]
  2. Alain C., Woods D. L., Knight R. T. A distributed cortical network for auditory sensory memory in humans. Brain Res. 1998 Nov 23;812(1-2):23–37. doi: 10.1016/s0006-8993(98)00851-8. [DOI] [PubMed] [Google Scholar]
  3. Alain C., Woods D. L., Ogawa K. H. Brain indices of automatic pattern processing. Neuroreport. 1994 Dec 30;6(1):140–144. doi: 10.1097/00001756-199412300-00036. [DOI] [PubMed] [Google Scholar]
  4. Alho K., Winkler I., Escera C., Huotilainen M., Virtanen J., Jäskeläinen I. P., Pekkonen E., Ilmoniemi R. J. Processing of novel sounds and frequency changes in the human auditory cortex: magnetoencephalographic recordings. Psychophysiology. 1998 Mar;35(2):211–224. [PubMed] [Google Scholar]
  5. Andreasen N. C., O'Leary D. S., Cizadlo T., Arndt S., Rezai K., Ponto L. L., Watkins G. L., Hichwa R. D. Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9985–9990. doi: 10.1073/pnas.93.18.9985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Baldeweg T., Williams J. D., Gruzelier J. H. Differential changes in frontal and sub-temporal components of mismatch negativity. Int J Psychophysiol. 1999 Aug;33(2):143–148. doi: 10.1016/s0167-8760(99)00026-4. [DOI] [PubMed] [Google Scholar]
  7. Bender S., Schall U., Wolstein J., Grzella I., Zerbin D., Oades R. D. A topographic event-related potential follow-up study on 'prepulse inhibition' in first and second episode patients with schizophrenia. Psychiatry Res. 1999 Feb 22;90(1):41–53. doi: 10.1016/s0925-4927(98)00053-5. [DOI] [PubMed] [Google Scholar]
  8. Catts S. V., Shelley A. M., Ward P. B., Liebert B., McConaghy N., Andrews S., Michie P. T. Brain potential evidence for an auditory sensory memory deficit in schizophrenia. Am J Psychiatry. 1995 Feb;152(2):213–219. doi: 10.1176/ajp.152.2.213. [DOI] [PubMed] [Google Scholar]
  9. Cowan N., Winkler I., Teder W., Nätänen R. Memory prerequisites of mismatch negativity in the auditory event-related potential (ERP). J Exp Psychol Learn Mem Cogn. 1993 Jul;19(4):909–921. doi: 10.1037//0278-7393.19.4.909. [DOI] [PubMed] [Google Scholar]
  10. Escera C., Alho K., Winkler I., Nätänen R. Neural mechanisms of involuntary attention to acoustic novelty and change. J Cogn Neurosci. 1998 Sep;10(5):590–604. doi: 10.1162/089892998562997. [DOI] [PubMed] [Google Scholar]
  11. Frangou S., Sharma T., Alarcon G., Sigmudsson T., Takei N., Binnie C., Murray R. M. The Maudsley Family Study, II: Endogenous event-related potentials in familial schizophrenia. Schizophr Res. 1997 Jan 17;23(1):45–53. doi: 10.1016/S0920-9964(96)00089-8. [DOI] [PubMed] [Google Scholar]
  12. Giraud A. L., Chéry-Croze S., Fischer G., Fischer C., Vighetto A., Grégoire M. C., Lavenne F., Collet L. A selective imaging of tinnitus. Neuroreport. 1999 Jan 18;10(1):1–5. doi: 10.1097/00001756-199901180-00001. [DOI] [PubMed] [Google Scholar]
  13. Grillon C., Courchesne E., Ameli R., Geyer M. A., Braff D. L. Increased distractibility in schizophrenic patients. Electrophysiologic and behavioral evidence. Arch Gen Psychiatry. 1990 Feb;47(2):171–179. doi: 10.1001/archpsyc.1990.01810140071010. [DOI] [PubMed] [Google Scholar]
  14. Hirayasu Y., Potts G. F., O'Donnell B. F., Kwon J. S., Arakaki H., Akdag S. J., Levitt J. J., Shenton M. E., McCarley R. W. Auditory mismatch negativity in schizophrenia: topographic evaluation with a high-density recording montage. Am J Psychiatry. 1998 Sep;155(9):1281–1284. doi: 10.1176/ajp.155.9.1281. [DOI] [PubMed] [Google Scholar]
  15. Javitt D. C., Doneshka P., Grochowski S., Ritter W. Impaired mismatch negativity generation reflects widespread dysfunction of working memory in schizophrenia. Arch Gen Psychiatry. 1995 Jul;52(7):550–558. doi: 10.1001/archpsyc.1995.03950190032005. [DOI] [PubMed] [Google Scholar]
  16. Javitt D. C., Doneshka P., Zylberman I., Ritter W., Vaughan H. G., Jr Impairment of early cortical processing in schizophrenia: an event-related potential confirmation study. Biol Psychiatry. 1993 Apr 1;33(7):513–519. doi: 10.1016/0006-3223(93)90005-x. [DOI] [PubMed] [Google Scholar]
  17. Javitt D. C., Grochowski S., Shelley A. M., Ritter W. Impaired mismatch negativity (MMN) generation in schizophrenia as a function of stimulus deviance, probability, and interstimulus/interdeviant interval. Electroencephalogr Clin Neurophysiol. 1998 Mar;108(2):143–153. doi: 10.1016/s0168-5597(97)00073-7. [DOI] [PubMed] [Google Scholar]
  18. Javitt D. C., Steinschneider M., Schroeder C. E., Vaughan H. G., Jr, Arezzo J. C. Detection of stimulus deviance within primate primary auditory cortex: intracortical mechanisms of mismatch negativity (MMN) generation. Brain Res. 1994 Dec 26;667(2):192–200. doi: 10.1016/0006-8993(94)91496-6. [DOI] [PubMed] [Google Scholar]
  19. Kasai K., Okazawa K., Nakagome K., Hiramatsu K., Hata A., Fukuda M., Honda M., Miyauchi M., Matsushita M. Mismatch negativity and N2b attenuation as an indicator for dysfunction of the preattentive and controlled processing for deviance detection in schizophrenia: a topographic event-related potential study. Schizophr Res. 1999 Jan 11;35(2):141–156. doi: 10.1016/s0920-9964(98)00116-9. [DOI] [PubMed] [Google Scholar]
  20. Kathmann N., Wagner M., Rendtorff N., Engel R. R. Delayed peak latency of the mismatch negativity in schizophrenics and alcoholics. Biol Psychiatry. 1995 May 15;37(10):754–757. doi: 10.1016/0006-3223(94)00309-Q. [DOI] [PubMed] [Google Scholar]
  21. Knight R. T., Nakada T. Cortico-limbic circuits and novelty: a review of EEG and blood flow data. Rev Neurosci. 1998;9(1):57–70. doi: 10.1515/revneuro.1998.9.1.57. [DOI] [PubMed] [Google Scholar]
  22. Kreitschmann-Andermahr I., Rosburg T., Meier T., Volz H. P., Nowak H., Sauer H. Impaired sensory processing in male patients with schizophrenia: a magnetoencephalographic study of auditory mismatch detection. Schizophr Res. 1999 Jan 11;35(2):121–129. doi: 10.1016/s0920-9964(98)00115-7. [DOI] [PubMed] [Google Scholar]
  23. Kropotov J. D., Nätnen R., Sevostianov A. V., Alho K., Reinikainen K., Kropotova O. V. Mismatch negativity to auditory stimulus change recorded directly from the human temporal cortex. Psychophysiology. 1995 Jul;32(4):418–422. doi: 10.1111/j.1469-8986.1995.tb01226.x. [DOI] [PubMed] [Google Scholar]
  24. Mathalon D. H., Ford J. M., Pfefferbaum A. Trait and state aspects of P300 amplitude reduction in schizophrenia: a retrospective longitudinal study. Biol Psychiatry. 2000 Mar 1;47(5):434–449. doi: 10.1016/s0006-3223(99)00277-2. [DOI] [PubMed] [Google Scholar]
  25. Mathalon D. H., Ford J. M., Rosenbloom M., Pfefferbaum A. P300 reduction and prolongation with illness duration in schizophrenia. Biol Psychiatry. 2000 Mar 1;47(5):413–427. doi: 10.1016/s0006-3223(99)00151-1. [DOI] [PubMed] [Google Scholar]
  26. McCarthy G., Wood C. C. Scalp distributions of event-related potentials: an ambiguity associated with analysis of variance models. Electroencephalogr Clin Neurophysiol. 1985 May;62(3):203–208. doi: 10.1016/0168-5597(85)90015-2. [DOI] [PubMed] [Google Scholar]
  27. Novak G. P., Ritter W., Vaughan H. G., Jr, Wiznitzer M. L. Differentiation of negative event-related potentials in an auditory discrimination task. Electroencephalogr Clin Neurophysiol. 1990 Apr;75(4):255–275. doi: 10.1016/0013-4694(90)90105-s. [DOI] [PubMed] [Google Scholar]
  28. Nätänen R., Alho K. Mismatch negativity--a unique measure of sensory processing in audition. Int J Neurosci. 1995;80(1-4):317–337. doi: 10.3109/00207459508986107. [DOI] [PubMed] [Google Scholar]
  29. Nätänen R., Lehtokoski A., Lennes M., Cheour M., Huotilainen M., Iivonen A., Vainio M., Alku P., Ilmoniemi R. J., Luuk A. Language-specific phoneme representations revealed by electric and magnetic brain responses. Nature. 1997 Jan 30;385(6615):432–434. doi: 10.1038/385432a0. [DOI] [PubMed] [Google Scholar]
  30. O'Donnell B. F., Faux S. F., McCarley R. W., Kimble M. O., Salisbury D. F., Nestor P. G., Kikinis R., Jolesz F. A., Shenton M. E. Increased rate of P300 latency prolongation with age in schizophrenia. Electrophysiological evidence for a neurodegenerative process. Arch Gen Psychiatry. 1995 Jul;52(7):544–549. doi: 10.1001/archpsyc.1995.03950190026004. [DOI] [PubMed] [Google Scholar]
  31. O'Donnell B. F., Hokama H., McCarley R. W., Smith R. S., Salisbury D. F., Mondrow E., Nestor P. G., Shenton M. E. Auditory ERPs to non-target stimuli in schizophrenia: relationship to probability, task-demands, and target ERPs. Int J Psychophysiol. 1994 Aug;17(3):219–231. doi: 10.1016/0167-8760(94)90065-5. [DOI] [PubMed] [Google Scholar]
  32. Oades R. D., Dittmann-Balcar A. Mismatch negativity (MMN) is altered by directing attention. Neuroreport. 1995 May 30;6(8):1187–1190. doi: 10.1097/00001756-199505300-00028. [DOI] [PubMed] [Google Scholar]
  33. Oades R. D., Dittmann-Balcar A., Zerbin D., Grzella I. Impaired attention-dependent augmentation of MMN in nonparanoid vs paranoid schizophrenic patients: a comparison with obsessive-compulsive disorder and healthy subjects. Biol Psychiatry. 1997 Jun 15;41(12):1196–1210. doi: 10.1016/s0006-3223(96)00214-4. [DOI] [PubMed] [Google Scholar]
  34. Oades R. D., Zerbin D., Dittmann-Balcar A., Eggers C. Auditory event-related potential (ERP) and difference-wave topography in schizophrenic patients with/without active hallucinations and delusions: a comparison with young obsessive-compulsive disorder (OCD) and healthy subjects. Int J Psychophysiol. 1996 Jun-Jul;22(3):185–214. doi: 10.1016/0167-8760(96)00026-8. [DOI] [PubMed] [Google Scholar]
  35. Olichney J. M., Iragui V. J., Kutas M., Nowacki R., Morris S., Jeste D. V. Relationship between auditory P300 amplitude and age of onset of schizophrenia in older patients. Psychiatry Res. 1998 Jul 13;79(3):241–254. doi: 10.1016/s0165-1781(98)00043-2. [DOI] [PubMed] [Google Scholar]
  36. Opitz B., Mecklinger A., Friederici A. D., von Cramon D. Y. The functional neuroanatomy of novelty processing: integrating ERP and fMRI results. Cereb Cortex. 1999 Jun;9(4):379–391. doi: 10.1093/cercor/9.4.379. [DOI] [PubMed] [Google Scholar]
  37. Paavilainen P., Tiitinen H., Alho K., Nätänen R. Mismatch negativity to slight pitch changes outside strong attentional focus. Biol Psychol. 1993 Oct;37(1):23–41. doi: 10.1016/0301-0511(93)90025-4. [DOI] [PubMed] [Google Scholar]
  38. Potts G. F., Hirayasu Y., O'Donnell B. F., Shenton M. E., McCarley R. W. High-density recording and topographic analysis of the auditory oddball event-related potential in patients with schizophrenia. Biol Psychiatry. 1998 Nov 15;44(10):982–989. doi: 10.1016/s0006-3223(98)00223-6. [DOI] [PubMed] [Google Scholar]
  39. Rey M. J., Schulz P., Costa C., Dick P., Tissot R. Guidelines for the dosage of neuroleptics. I: Chlorpromazine equivalents of orally administered neuroleptics. Int Clin Psychopharmacol. 1989 Apr;4(2):95–104. doi: 10.1097/00004850-198904000-00001. [DOI] [PubMed] [Google Scholar]
  40. Ritter W., Simson R., Vaughan H. G., Jr, Friedman D. A brain event related to the making of a sensory discrimination. Science. 1979 Mar 30;203(4387):1358–1361. doi: 10.1126/science.424760. [DOI] [PubMed] [Google Scholar]
  41. Saigusa T., Tuinstra T., Koshikawa N., Cools A. R. High and low responders to novelty: effects of a catecholamine synthesis inhibitor on novelty-induced changes in behaviour and release of accumbal dopamine. Neuroscience. 1999;88(4):1153–1163. doi: 10.1016/s0306-4522(98)00275-9. [DOI] [PubMed] [Google Scholar]
  42. Sams M., Paavilainen P., Alho K., Nätänen R. Auditory frequency discrimination and event-related potentials. Electroencephalogr Clin Neurophysiol. 1985 Nov;62(6):437–448. doi: 10.1016/0168-5597(85)90054-1. [DOI] [PubMed] [Google Scholar]
  43. Schall Ulrich, Catts Stanley V., Chaturvedi Shail, Liebert Barbara, Redenbach Joanna, Karayanidis Frini, Ward Philip B. The effect of clozapine therapy on frontal lobe dysfunction in schizophrenia: neuropsychology and event-related potential measures. Int J Neuropsychopharmacol. 1998 Jul;1(1):19–29. doi: 10.1017/S146114579800100X. [DOI] [PubMed] [Google Scholar]
  44. Schall Ulrich, Catts Stanley V., Karayanidis Frini, Ward Philip B. Auditory event-related potential indices of fronto-temporal information processing in schizophrenia syndromes: valid outcome prediction of clozapine therapy in a three-year follow-up. Int J Neuropsychopharmacol. 1999 Jun;2(2):83–93. doi: 10.1017/S1461145799001418. [DOI] [PubMed] [Google Scholar]
  45. Schroeder M. M., Ritter W., Vaughan H. G., Jr The mismatch negativity to novel stimuli reflects cognitive decline. Ann N Y Acad Sci. 1995 Dec 15;769:399–401. doi: 10.1111/j.1749-6632.1995.tb38155.x. [DOI] [PubMed] [Google Scholar]
  46. Shelley A. M., Silipo G., Javitt D. C. Diminished responsiveness of ERPs in schizophrenic subjects to changes in auditory stimulation parameters: implications for theories of cortical dysfunction. Schizophr Res. 1999 May 4;37(1):65–79. doi: 10.1016/s0920-9964(98)00138-8. [DOI] [PubMed] [Google Scholar]
  47. Shelley A. M., Ward P. B., Catts S. V., Michie P. T., Andrews S., McConaghy N. Mismatch negativity: an index of a preattentive processing deficit in schizophrenia. Biol Psychiatry. 1991 Nov 15;30(10):1059–1062. doi: 10.1016/0006-3223(91)90126-7. [DOI] [PubMed] [Google Scholar]
  48. Shutara Y., Koga Y., Fujita K., Takeuchi H., Mochida M., Takemasa K. An event-related potential study on the impairment of automatic processing of auditory input in schizophrenia. Brain Topogr. 1996 Spring;8(3):285–289. doi: 10.1007/BF01184786. [DOI] [PubMed] [Google Scholar]
  49. Simpson G. M., Angus J. W. A rating scale for extrapyramidal side effects. Acta Psychiatr Scand Suppl. 1970;212:11–19. doi: 10.1111/j.1600-0447.1970.tb02066.x. [DOI] [PubMed] [Google Scholar]
  50. Sussman E., Winkler I., Ritter W., Alho K., Nätänen R. Temporal integration of auditory stimulus deviance as reflected by the mismatch negativity. Neurosci Lett. 1999 Apr 2;264(1-3):161–164. doi: 10.1016/s0304-3940(99)00214-1. [DOI] [PubMed] [Google Scholar]
  51. Trejo L. J., Ryan-Jones D. L., Kramer A. F. Attentional modulation of the mismatch negativity elicited by frequency differences between binaurally presented tone bursts. Psychophysiology. 1995 Jul;32(4):319–328. doi: 10.1111/j.1469-8986.1995.tb01214.x. [DOI] [PubMed] [Google Scholar]
  52. Turetsky B., Colbath E. A., Gur R. E. P300 subcomponent abnormalities in schizophrenia: II. Longitudinal stability and relationship to symptom change. Biol Psychiatry. 1998 Jan 1;43(1):31–39. doi: 10.1016/s0006-3223(97)00261-8. [DOI] [PubMed] [Google Scholar]
  53. Umbricht D., Javitt D., Novak G., Bates J., Pollack S., Lieberman J., Kane J. Effects of clozapine on auditory event-related potentials in schizophrenia. Biol Psychiatry. 1998 Oct 15;44(8):716–725. doi: 10.1016/s0006-3223(97)00524-6. [DOI] [PubMed] [Google Scholar]
  54. Woldorff M. G., Hillyard S. A., Gallen C. C., Hampson S. R., Bloom F. E. Magnetoencephalographic recordings demonstrate attentional modulation of mismatch-related neural activity in human auditory cortex. Psychophysiology. 1998 May;35(3):283–292. doi: 10.1017/s0048577298961601. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Psychiatry and Neuroscience are provided here courtesy of Canadian Medical Association

RESOURCES