Multiple sequence alignment of the p57 orthologs from L.
seymouri (Lsp57), L. major (Lmp57, accession no.
AC058781), T. brucei (Tbp57, TRYP9.0.000918; Sanger
Center, Cambridge, U.K.), and HeLa SNAP50
(hSNAP50, accession no. HSU71300). The alignment was obtained by using
the clustalw program. The peptides overlined above the
L. seymouri sequence were obtained from peptide
sequencing. The C4-type zinc finger conserved among the proteins is
boxed. SNAP50 has an additional zinc finger located upstream from the
boxed region. The black shade means that the residues either are
identical or conserved substitution in all four sequences. The medium
shade means identical or conserved substitution in three of four
sequences. The light shade means the same in two sequences.