TABLE 1.
Neutralizing antibody titer from vaccinated mice and rabbits
| Mouse group | Rabbit group
|
|||
|---|---|---|---|---|
| DNA inoculum (wk 0 and 6) | DNA inoculum titer (wk 12 and 18) | gp120IIIB protein inoculum titer (wk 12 and 18) | DNA inoculum (wk 0, 6, 12, and 18) | gp120IIIB protein inoculum titer (wk 27) |
| sgp120IIIBa | NTc | <1:20b | sgp120IIIBa | <1:20b |
| sgp120IIIB-mC3d1 | <1:20 | 1:27 | sgp120IIIB-hC3d3 | 1:160 |
| sgp120IIIB-mC3d2 | 1:36 | 1:33 | sgp12089.6 | <1:20 |
| sgp120IIIB-mC3d3 | 1:45 | 1:80 | sgp12089.6-hC3d3 | 1:80 |
a
Sera were tested against each homologous strain, and the titers are shown. Sera tested against the heterologous strain did not show neutralizing titers above background. The preimmune sera titer has been deducted from each sample.
b
Titers are the sample dilution at which 50% of the MT-2 cells were protected from virus-induced killing as measured by neutral red uptake.
c
NT, not tested.