TABLE 1.

Outcome of LCMV/WE infection of rhesus macaques

Monkey	Inoculation route and dose (PFU)	Outcome	Viremiaa	Virus in liverb	Antibody responsec
Rh-iv3	i.v., 103	Died	1.0 × 106	5.5 × 105	<2 (E), negative (N)
Rh-iv6	i.v., 106	Died	1.2 × 107	1.0 × 108	<2 (E), negative (N)
Rh-ig6a	i.g., 106	Survived	PCR negative	PCR negative	<2 (E), negative (N)
Rh-ig6b	i.g., 106	Survived	PCR negative	PCR negative	<2 (E), negative (N)
Rh-ig7a	i.g., 107	Survived	PCR negative	PCR negative	<2 (E), negative (N)
Rh-ig7b	i.g., 107	Illness and full recovery	8.8 × 104	PCR positive and negatived	7.2 (E), 3.1 (N)

^aFor Rh-iv3 and Rh-iv6, viremia on day of death is shown (in PFU per milliliter). For Rh-ig7b, viremia was detected on day 28 p.i. and was not detectable by plaque assay and RT-PCR on day 42 and later.

^bRT-PCR was performed with RNA samples extracted from livers of Rh-iv3 and Rh-iv6 on the day of death and from Rh-ig6a and Rh-ig6b on day 28, when the animals were sacrificed. For Rh-ig7a and Rh-ig7b, biopsies were performed before the infection and at weeks 4 and 11 p.i. Titers are in PFU per gram of tissue.

^cAntibody response was evaluated in ELISA (E) and in plaque reduction neutralization assay (N) and expressed as 1/log₁₀ of the final serum dilution (see Materials and Methods for details).

^dRh-ig7b was RT-PCR negative for virus before infection and at weeks 2 and 6 after infection and was RT-PCR positive at week 4 after infection.