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. 2002 Dec 30;100(1):223–228. doi: 10.1073/pnas.0237082100

Figure 2.

Figure 2

PXR target genes show enhanced hepatic expression in the Cyp27a1−/− mouse. mRNA was isolated from the livers of chow-fed, male, wild-type and Cyp27a1−/− mice of a mixed-strain background (C57BL/6:129Sv). Northern analysis was performed, quantified by PhosphorImager, standardized against β-actin, and mathematically adjusted to yield a value of 1 for the wild-type group (white bars). The relative expression values (black bars) are depicted as the mean and SEM for each genotype (n = 6), and asterisks denote statistically significant results as determined by Student's t test (*, P < 0.05; ***, P < 0.0001).