Table 1.

Relationships between CYP7A1/CYP27A1 expression and CYP3A11

Mouse model	mRNA expression			Ref.
	CYP7A1	CYP27A1	CYP3A11
Dietary manipulations
2% cholesterol feeding (7 d)	↑ 2×	NC	↑ ≈50%	J.J.R., unpublished
LXR agonist feeding (7 d)	↑ 6×	NC	↑ 2×	J.J.R., unpublished
Knockout mice
Cyp27a1−/−	↑ 10×	Absent	↑ 10×	Current study
Cyp7a1−/−	Absent	NC	↓ ≈50%	J.J.R., unpublished
Fxr−/−	↑ 2×	↓ ≈75%	↑	31
Pxr−/−	↓ ≈50%	NC	↑ 4×	32
Liver conditional Rxrα−/−	↑	?	↓	33

The hepatic mRNA expression levels for these three genes are expressed relative to wild-type, chow-fed mice. 

References are given for studies that measured both CYP7A1 and CYP3A11. NC, no change; LXR, liver X receptor; ?, not determined.