Abstract
Clearance of T1 or T2 bacteriophage from the circulation of rabbits takes place in two phases; a rapid first phase and a slower second phase. Secondary stimulation of rabbits with a similar dose of phage to the primary dose results in a more rapid clearance of bacteriophage particles from the circulation. This increased rate of clearance can be demonstrated prior to the production of any detectable humoral antibody. The enhanced secondary clearance appears to be specific for the particle concerned, and does not occur using non-antigenic carbon particles.
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Selected References
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