Skip to main content
Immunology logoLink to Immunology
. 1968 Dec;15(6):845–854.

The reaction of heart and other organ extracts with the sera of animals immunized with group A streptococci

I M Lyampert, N A Borodiyuk, G A Ugryumova
PMCID: PMC1409493  PMID: 4179325

Abstract

Extracts of guinea-pig skeletal muscle, heart, kidney and liver tissues contain soluble antigens which react in gel precipitation and immunoelectrophoresis with sera of animals immunized with group A streptococci, and with γ-globulin preparations obtained from these sera. These are specific immunological reactions. The antigens in extracts of heart tissue and other organs are proteins. They are cross-reactive antigens since absorption of sera with homologous strains of streptococci abolishes these reactions.

Full text

PDF
845

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boyden S. V. Natural antibodies and the immune response. Adv Immunol. 1966;5:1–28. doi: 10.1016/s0065-2776(08)60271-0. [DOI] [PubMed] [Google Scholar]
  2. Chase R. M., Jr, Rapaport F. T. The bacterial induction of homograft sensitivity. I. Effects of sensitization with group A streptococci. J Exp Med. 1965 Oct 1;122(4):721–732. doi: 10.1084/jem.122.4.721. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. KAPLAN M. H. IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. I. PROPERTIES OF AN ANTIGEN IN CERTAIN STRAINS OF GROUP A STREPTOCOCCI EXHIBITING AN IMMUNOLOGIC CROSS-REACTION WITH HUMAN HEART TISSUE. J Immunol. 1963 Apr;90:595–606. [PubMed] [Google Scholar]
  4. KAPLAN M. H., SUCHY M. L. IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. II. CROSS-REACTION OF ANTISERA TO MAMMALIAN HEART TISSUE WITH A CELL WALL CONSTITUENT OF CERTAIN STRAINS OF GROUP A STREPTOCOCCI. J Exp Med. 1964 Apr 1;119:643–650. doi: 10.1084/jem.119.4.643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Kaplan M. H. Autoantibodies to heart and rheumatic fever: the induction of autoimmunity to heart by streptococcal antigen cross-reactive with heart. Ann N Y Acad Sci. 1965 Jun 30;124(2):904–915. doi: 10.1111/j.1749-6632.1965.tb19014.x. [DOI] [PubMed] [Google Scholar]
  6. Lyampert I. M., Danilova T. A., Borodyuk N. A., Beletskaya L. V. Mechanism of formation of antibodies to heart tissue in immunization with group A streptococci. Folia Biol (Praha) 1966;12(2):108–115. [PubMed] [Google Scholar]
  7. Lyampert I. M., Vvedenskaya O. I., Danilova T. A. Study on streptococcus group A antigens common with heart tissue elements. Immunology. 1966 Oct;11(4):313–320. [PMC free article] [PubMed] [Google Scholar]
  8. MARKOWITZ A. S., LANGE C. F., Jr STREPTOCOCCAL RELATED GLOMERULONEPHRITIS. I. ISOLATION, IMMUNOCHEMISTRY AND COMPARATIVE CHEMISTRY OF SOLUBLE FRACTIONS FROM TYPE 12 NEPHRITOGENIC STREPTOCOCCI AND HUMAN GLOMERULI. J Immunol. 1964 Apr;92:565–575. [PubMed] [Google Scholar]
  9. MAURER P. H., GERULAT B. F., PINCHUCK P. ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS). XII. IMMUNOLOGICAL STUDIES WITH A NEW GROUP OF SYNTHETIC COPOLYMERS. J Exp Med. 1964 Jan 1;119:1005–1015. doi: 10.1084/jem.119.6.1005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mekler L. B. Genetic information used during synthesis of virus components and antivirus immunity. Nature. 1965 Apr 24;206(982):343–346. doi: 10.1038/206343a0. [DOI] [PubMed] [Google Scholar]
  11. Perlmann P., Hammarström S., Lagercrantz R., Gustafsson B. E. Antigen from colon of germfree rats and antibodies in human ulcerative colitis. Ann N Y Acad Sci. 1965 Jun 30;124(1):377–394. doi: 10.1111/j.1749-6632.1965.tb18972.x. [DOI] [PubMed] [Google Scholar]
  12. ROWLEY D., JENKIN C. R. Antigenic cross-reaction between host and parasite as a possible cause of pathogenicity. Nature. 1962 Jan 13;193:151–154. doi: 10.1038/193151a0. [DOI] [PubMed] [Google Scholar]
  13. TOMASI T. B. A precipitation reaction between human serum and a soluble tissue component. J Immunol. 1961 Apr;86:427–430. [PubMed] [Google Scholar]
  14. Weigle W. O. The antibody response in rabbits to previously tolerated antigens. Ann N Y Acad Sci. 1965 Jun 30;124(1):133–142. doi: 10.1111/j.1749-6632.1965.tb18949.x. [DOI] [PubMed] [Google Scholar]
  15. Zabriskie J. B., Freimer E. H. An immunological relationship between the group. A streptococcus and mammalian muscle. J Exp Med. 1966 Oct 1;124(4):661–678. doi: 10.1084/jem.124.4.661. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES