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. 1968 Dec;15(6):845–854.

The reaction of heart and other organ extracts with the sera of animals immunized with group A streptococci

I M Lyampert, N A Borodiyuk, G A Ugryumova
PMCID: PMC1409493  PMID: 4179325

Abstract

Extracts of guinea-pig skeletal muscle, heart, kidney and liver tissues contain soluble antigens which react in gel precipitation and immunoelectrophoresis with sera of animals immunized with group A streptococci, and with γ-globulin preparations obtained from these sera. These are specific immunological reactions. The antigens in extracts of heart tissue and other organs are proteins. They are cross-reactive antigens since absorption of sera with homologous strains of streptococci abolishes these reactions.

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Selected References

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  1. Boyden S. V. Natural antibodies and the immune response. Adv Immunol. 1966;5:1–28. doi: 10.1016/s0065-2776(08)60271-0. [DOI] [PubMed] [Google Scholar]
  2. Chase R. M., Jr, Rapaport F. T. The bacterial induction of homograft sensitivity. I. Effects of sensitization with group A streptococci. J Exp Med. 1965 Oct 1;122(4):721–732. doi: 10.1084/jem.122.4.721. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. KAPLAN M. H. IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. I. PROPERTIES OF AN ANTIGEN IN CERTAIN STRAINS OF GROUP A STREPTOCOCCI EXHIBITING AN IMMUNOLOGIC CROSS-REACTION WITH HUMAN HEART TISSUE. J Immunol. 1963 Apr;90:595–606. [PubMed] [Google Scholar]
  4. KAPLAN M. H., SUCHY M. L. IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. II. CROSS-REACTION OF ANTISERA TO MAMMALIAN HEART TISSUE WITH A CELL WALL CONSTITUENT OF CERTAIN STRAINS OF GROUP A STREPTOCOCCI. J Exp Med. 1964 Apr 1;119:643–650. doi: 10.1084/jem.119.4.643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Kaplan M. H. Autoantibodies to heart and rheumatic fever: the induction of autoimmunity to heart by streptococcal antigen cross-reactive with heart. Ann N Y Acad Sci. 1965 Jun 30;124(2):904–915. doi: 10.1111/j.1749-6632.1965.tb19014.x. [DOI] [PubMed] [Google Scholar]
  6. Lyampert I. M., Danilova T. A., Borodyuk N. A., Beletskaya L. V. Mechanism of formation of antibodies to heart tissue in immunization with group A streptococci. Folia Biol (Praha) 1966;12(2):108–115. [PubMed] [Google Scholar]
  7. Lyampert I. M., Vvedenskaya O. I., Danilova T. A. Study on streptococcus group A antigens common with heart tissue elements. Immunology. 1966 Oct;11(4):313–320. [PMC free article] [PubMed] [Google Scholar]
  8. MARKOWITZ A. S., LANGE C. F., Jr STREPTOCOCCAL RELATED GLOMERULONEPHRITIS. I. ISOLATION, IMMUNOCHEMISTRY AND COMPARATIVE CHEMISTRY OF SOLUBLE FRACTIONS FROM TYPE 12 NEPHRITOGENIC STREPTOCOCCI AND HUMAN GLOMERULI. J Immunol. 1964 Apr;92:565–575. [PubMed] [Google Scholar]
  9. MAURER P. H., GERULAT B. F., PINCHUCK P. ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS). XII. IMMUNOLOGICAL STUDIES WITH A NEW GROUP OF SYNTHETIC COPOLYMERS. J Exp Med. 1964 Jan 1;119:1005–1015. doi: 10.1084/jem.119.6.1005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mekler L. B. Genetic information used during synthesis of virus components and antivirus immunity. Nature. 1965 Apr 24;206(982):343–346. doi: 10.1038/206343a0. [DOI] [PubMed] [Google Scholar]
  11. Perlmann P., Hammarström S., Lagercrantz R., Gustafsson B. E. Antigen from colon of germfree rats and antibodies in human ulcerative colitis. Ann N Y Acad Sci. 1965 Jun 30;124(1):377–394. doi: 10.1111/j.1749-6632.1965.tb18972.x. [DOI] [PubMed] [Google Scholar]
  12. ROWLEY D., JENKIN C. R. Antigenic cross-reaction between host and parasite as a possible cause of pathogenicity. Nature. 1962 Jan 13;193:151–154. doi: 10.1038/193151a0. [DOI] [PubMed] [Google Scholar]
  13. TOMASI T. B. A precipitation reaction between human serum and a soluble tissue component. J Immunol. 1961 Apr;86:427–430. [PubMed] [Google Scholar]
  14. Weigle W. O. The antibody response in rabbits to previously tolerated antigens. Ann N Y Acad Sci. 1965 Jun 30;124(1):133–142. doi: 10.1111/j.1749-6632.1965.tb18949.x. [DOI] [PubMed] [Google Scholar]
  15. Zabriskie J. B., Freimer E. H. An immunological relationship between the group. A streptococcus and mammalian muscle. J Exp Med. 1966 Oct 1;124(4):661–678. doi: 10.1084/jem.124.4.661. [DOI] [PMC free article] [PubMed] [Google Scholar]

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