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. Author manuscript; available in PMC: 2006 Mar 22.
Published in final edited form as: Anesth Analg. 2005 Nov;101(5):1433–1439. doi: 10.1213/01.ANE.0000180998.29890.B0

Figure 2.

Figure 2

The magnitude and time course of changes in pain score and weight distribution ratio after injections of carrageenan and resiniferatoxin. Pain score: – a cumulative score based on walking patterns observed during an 1-hour period. Weight distribution ratio: – a ratio of weight distribution between left (inflamed) and right (contralateral control) hind legs of the sitting rat. Each column represents the mean ± SD for the carrageenan-bupivacaine-resiniferatoxin (CBR) group and the carrageenan-bupivacaine-vehicle (CBV) group (n=8 per group). Carrageenan (C: −2%, 30μL), bupivacaine (B: −0.5%, 10μL), resiniferatoxin (R: −0.0003%, 30 μL), or vehicle (V: −30 μL) were injected into the left knee-joint cavity. Time: − h (hours) or d (days) before (−) or after the injection of resiniferatoxin. Statistical significance: aP < 0.0001 vs. CBV at 3 h, bP<0.01 vs. CBV at 24 h, cP< 0.02 vs. CBV at 3 h, dP<0.02 vs. CBV at 24 h, eP< 0.05 vs. CBV at 3d.