Figure 4.

The effect of resiniferatoxin on the carrageenan-induced increase in the knee circumference. CBR: -- carrageenan-bupivacaine-resiniferatoxin group; CBV: -- carrageenan-bupivacaine-vehicle group (n=8 per group). Carrageenan (C: −2%, 30μL), bupivacaine (B: −0.5%, 10μL), resiniferatoxin (R: −0.0003%, 30μL) or vehicle (V: −30μL) was injected into the knee-joint cavity. Boxes display differences in the increases (Δ) of the knee circumference (mean ± SD) from baseline level in the CBR group (upper line) vs. the CBV group (lower line) at 24h (A) and 3d (B).