Figure 7. Dysregulation of hepatic and skeletal muscle glucose homeostasis in FXR^–/– mice.

Loss of FXR function in the liver results in increased hepatic lipid accumulation and elevation of FFAs in the serum. Insulin resistance both in the liver, which fails to suppress gluconeogenesis, and in the skeletal muscle, which reduces glucose uptake, contributes to dysregulation of glucose homeostasis in FXR^–/– mice.