Table 4.
The penalty points for example 3
| # 1–6 from Table 1 | Penalty |
| 1 Yield: 83% | 9 |
| 2 Formamide (1 mL) | 0 |
| Pd(OAc)2 (0.038 mmol, 8.5 mg) | 0 |
| dppf (0.038 mmol, 21.1 mg) | 0 |
| Imidazole (0.75 mmol. 51.1 mg) | 0 |
| KOBu-t (1.13 mmol, 126 mg) | 0 |
| 3 Bromobenzene (N) | 5 |
| Formamide (T) | 5 |
| KOBu-t (F) | 5 |
| dppf (T) | 5 |
| 4 Microwave activation | 2 |
| Nitrogen atmosphere | 1 |
| 5 180°C, 400 s | 2 |
| 6 Cooling | 0 |
| Dilution with EtOAc | 0 |
| Washing with water and brine | 3 |
| Drying over potassium carbonate | 0 |
| Removal of EtOAc | 0 |
| Silica gel chromatography | 10 |
| Penalty points total: | 47 |