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. 2006 Mar 3;2:3. doi: 10.1186/1860-5397-2-3

Table 5.

The penalty points for example 4

# 1–6 from Table 1 Penalty

1 Yield: 76% 12
2 HMDS (4 equiv.) 0
CO (in excess) 0
PdCl2 (0.03 equiv.) 0
PPh3 (0.06 equiv.) 0
DMF 0
3 CO (T, F+) 15
HMDS (F) 5
DMF (T) 5
PPh3 (N) 5
Bromobenzene (N) 5
4 Controlled addition 1
CO atmosphere 1
5 80°C, 1.5 h 3
6 Cooling 0
Addition MeOH 0
Addition 2N H2SO4 0
Extraction with AcOEt 3
Washing with aq.NaHCO3 and brine 3
Silica gel chromatography 10

Penalty points total: 68