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. 2006 Feb 6;7:53. doi: 10.1186/1471-2105-7-53

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Copyright © 2006 von Grotthuss et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FSSP (on the left) and 3D-Fun (on the right) Z-score of the most similar protein with the same enzyme function at the 1^stand 2^ndEC level versus Z-score of the most similar protein with different enzyme function at the 1^stor 2^ndEC level. Calculation was conducted for 3,135 sequentially non-redundant structures of known function. Corresponding histograms are shown below the charts. If FSSP Z-score = 15 and 3D-Fun Z-score = 7 were used as a cutoff value we would obtain sensitivity of 73% and 79% with specificity at 68% and 70%, respectively.