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. Author manuscript; available in PMC: 2007 Apr 1.
Published in final edited form as: J Neurophysiol. 2006 Jan 18;95(4):2155–2166. doi: 10.1152/jn.00603.2005

5.

5.

Nicotine does not affect responses to NMDA applied by pressure ejection. A, average current traces from a representative experiment. The arrowhead bar shows the time of onset of the NMDA pulse (1 mM, 20 PSI, 3 ms). Average traces are shown in the absence of any additional drug (control, top) and in the presence of bath applied 10 μM nicotine. 50 μM D-AP5 reversibly abolished NMDA-induced depolarization. Bottom trace, pressure ejection of ACSF alone produces no response. B, time course of peak voltage amplitudes from the experiment shown in A. Sliding boxcar average is shown (width = 19 points). C, average time course for nicotine (n= 6 neurons), normalized to control value.