Table 2.

Gene Ontology Biological Process classification of the 410 most differentially expressed genes as indicated by the microarray data

Categories	Upregulated in obese subjects	Downregulated in obese subjects	p value of category over-representation a	p value of difference in the number of upregulated vs down regulated genes a
Inflammation/immune response	52	2	0.0008	<0.00001
Signalling	25	17	0.001
Transcription regulation	12	22	0.002
Cell cycle control/cell proliferation	24	8		0.002
Cell adhesion	26	2		<0.00001
Transport/carrier	18	14
Structural protein/cytoskeleton organisation	21	2		<0.00001
Apoptosis	14	6		0.04
Protein biosynthesis/folding	6	11
Carbohydrate metabolism	6	11
Energy pathway/electron transport	3	14		0.01
Protein modification	8	7
Nucleic acid metabolism	8	6
Proteolysis/peptidolysis	11	2		0.003
Lipid metabolism	5	7
Amino acid metabolism	4	6
Response to stress	6	3
Cell growth and maintenance	6	1		0.01
Fatty acid metabolism	1	7
Blood coagulation	6	0		0.03

^aOnly p values <0.05 are presented