Table 2.
Inflammation-related genes
| Gene name | Gene symbol | Microarray |
Quantitative RT-PCR |
||
|---|---|---|---|---|---|
| Fold change (obese/non-obese) | p value of difference in expression c | Fold change (obese/non-obese) | p value of difference in expression c | ||
| Chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | CCL18 d | 2.15 | 0.003 | 5.0 | 0.07 |
| Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | PLA2G7 d | 1.94 | 0.004 | 3.8 | 0.01 |
| Cathepsin S | CTSS a | 1.93 | 0.002 | 4.3 | 0.01 |
| Major histocompatibility complex, class II, DR beta 1 | HLA-DRB3 | 1.93 | 0.006 | ||
| Major histocompatibility complex, class II, DR alpha | HLA-DRA d | 1.78 | 0.009 | 3.6 | 0.05 |
| Macrophage scavenger receptor 1 | MSR1 | 1.73 | 0.008 | ||
| Integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit | ITGB2 d | 1.7 | 0.008 | 3.6 | 0.01 |
| Major histocompatibility complex, class II, DQ alpha 1 | HLA-DQA1 | 1.65 | 0.005 | ||
| CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) | CD74 | 1.62 | 0.009 | ||
| B cell RAG associated protein | GALNAC4S-6ST | 1.56 | 0.007 | ||
| CD53 antigend | CD53 a | 1.53 | 0.005 | 2.9 | 0.03 |
| Decay accelerating factor for complement (CD55, Cromer blood group system) | DAF d | 1.53 | 0.005 | 1.0 | 0.1 |
| FYN binding protein (FYB-120/130 | FYB | 1.51 | 0.004 | ||
| Interleukin 8 | IL8 d | 1.5 | 0.002 | 4.0 | 0.01 |
| Major histocompatibility complex, class II, DM beta | HLA-DMB | 1.45 | 0.008 | ||
| Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | ICAM1 d | 1.41 | 0.005 | 1.6 | 0.2 |
| Lymphocyte antigen 96 | LY96 | 1.27 | 0.004 | ||
| Membrane cofactor protein (CD46, trophoblastlymphocyte cross-reactive antigen) | MCP | −1.19 | 0.005 | ||
| Annexin A11 | ANXA11 | −1.28 | 0.007 | ||
| CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) | CD59 a, b, d | −1.28 | 0.001 | 1.2 | 0.46 |
| T-cell immunomodulatory protein | CDA08 | −1.29 | 0.009 | ||
| Protein C receptor, endothelial (EPCR) | PROCR | −1.5 | 0.003 | ||
| Cysteine-rich protein 1 (intestinal) | CRIP1 | −3.76 | 0.002 | ||
The expression levels of the genes in bold font were examined by quantitative RT-PCR
a
Also differentially expressed in the adipocyte microarray dataset [3] and compared by quantitative RT-PCR in preadipocytes/SVC and adipocytes
b
Upregulated in adipocytes and downregulated in preadipocytes/SVC of obese subjects in the microarray experiments
c
A p value <0.05 was considered significant
d
Genes examined by quantitative RT-PCR