TABLE 1.

Pairwise alignment of representative sequences of avian and mammalian IFN with zfIFN

IFN	% Identity/similaritya with:
	Human IFN-α	Human IFN-β	Mouse IFN-α	Chicken IFN-α	Chicken IFN-β	zfIFN
Human IFN-α		38/54	59/75	24/49	22/44	25/53
Human IFN-β	32/52		28/49	28/51	24/47	24/44
Mouse IFN-α	59/75	25/44		20/38	20/41	32/55
Chicken IFN-α	20/40	21/40	19/37		55/67	22/43
Chicken IFN-β	17/41	19/38	16/36	47/61		21/41
zfIFN	15/34	14/36	16/34	18/38	16/39

^aNumbers below the diagonal represent percentages of identity or similarity over the entire sequence, and numbers above the diagonal represent alignments in which the N-terminal 70 amino acids were removed from each sequence. The region from amino acids 70 to 170 of each group 1 IFN sequence represents a conserved domain.