Table 2.
Comparison of thrombin parameters from the case and control populations
| N | Max R OR (95% CI) | CT,s mean (SD) | MaxL, nM mean (SD) | AUC,μ M•s Mean (SD) | MaxR,nM/s mean (SD) | TimeMaxL,s mean (SD) | |
|---|---|---|---|---|---|---|---|
| Whole population – cases | 426 | 2.6 | 372(72) | 450(96) | 98(24) | 3.5(1.0) | 698(87) |
| controls | 473 | (1.8–3.8) | 393(80) | 412(83) | 92(19) | 3.0(0.8) | 730(96) |
| Sex/Men – cases | 172 | 3.9 | 382(68) | 442(89) | 98(23) | 3.4(0.9) | 713(81) |
| controls | 201 | (2.0–7.5) | 412(80) | 399(81) | 90(18) | 2.9(0.8) | 751(93) |
| Sex/Women- cases | 254 | 2.1 | 365(75) | 456(100) | 98(24) | 3.6(1.0) | 688(89) |
| controls | 272 | (1.4–3.3) | 379(78) | 421(84) | 93(19) | 3.1(0.9) | 714(96) |
| Females without OCa | |||||||
| Cases | 40 | 8.8b | 357(83) | 464(121) | 101(35) | 3.6(1.2) | 681(94) |
| Controls | 90 | (3.2–23.7) | 408(74) | 388(65) | 87(15) | 2.8(0.6) | 750(87) |
| Females with OCa | |||||||
| Cases | 30 | 2.9 | 310(79) | 520(124) | 112(29) | 4.3(1.2) | 623(95) |
| Controls | 47 | (1.1–7.7) | 311(71) | 472(92) | 100(21) | 3.8(1.0) | 625(87) |
| +OC patients versus −OC controlsa | |||||||
| Cases | 30 | 27.7 b | 310(79) | 520(124) | 112(29) | 4.3(1.2) | 623(95) |
| Controls | 90 | (9.2–82.9) | 408(74) | 388(65) | 87(15) | 2.8(0.6) | 750(87) |
| Age (yrs) | |||||||
| <=45 - cases | 209 | 2.8 | 366(78) | 446(106) | 98(27) | 3.4(1.0) | 697(94) |
| - controls | 223 | (1.7–4.8) | 398(88) | 401(85) | 90(18) | 2.9(0.9) | 738(106) |
| >45 - cases | 217 | 2.5 | 377(66) | 455(85) | 98(20) | 3.5(0.9 | 699(79) |
| - controls | 250 | (1.5–4.0) | 388(72) | 421(81) | 94(19) | 3.1(0.8) | 723(87) |
| Smoke | |||||||
| Yes - cases | 155 | 2.5 | 376(74) | 449(107) | 99(28) | 3.4(1.0) | 707(90) |
| - controls | 168 | (1.3–4.5) | 392(85) | 412(82) | 92(19) | 3.0(0.8) | 732(102) |
| No - cases | 271 | 2.7 | 369(71) | 451(89) | 98(21) | 3.5(0.9) | 693(85) |
| - controls | 305 | (1.7–4.3) | 393(78) | 411(84) | 92(19) | 3.1(0.8) | 729(93) |
| Alcohol | |||||||
| None - cases | 135 | 3.2 | 372(76) | 458(91) | 98(20) | 3.6(1.0) | 696(93) |
| - controls | 111 | (1.6–6.3) | 384(77) | 417(79) | 93(18) | 3.1(0.8) | 722(90) |
| <=1 - cases | 175 | 2.0 | 374(73) | 439(91) | 96(24) | 3.4(0.9) | 699(85) |
| - controls | 222 | (1.2–3.4) | 394(82) | 410(83) | 91(19) | 3.0(0.9) | 732(103) |
| 2–4 - cases | 95 | 2.7 | 370(68) | 453(94) | 99(23) | 3.5(0.9) | 699(84) |
| - controls | 124 | (1.2–6.0) | 396(82) | 408(87) | 91(19) | 3.0(0.8) | 731(90) |
| 5–10 - cases | 13 | 6.3 | 349(69) | 511(174) | 119(51) | 4.0(1.7) | 682(90) |
| -controls | 11 | (0.6–64.9) | 395(92) | 425(101) | 96(23) | 3.1(0.8) | 736(107) |
| BMI kg/m2 | |||||||
| <=26 - cases | 206 | 2.9 | 386(78) | 429(91) | 93(21) | 3.3(0.9) | 712(91) |
| - controls | 275 | (1.6–5.0) | 409(83) | 394(78) | 88(17) | 2.9(0.8) | 748(99) |
| >26 - cases | 216 | 2.3 | 356(61) | 473(95) | 103(26) | 3.7(1.0) | 681(77) |
| - controls | 193 | (1.4–3.8) | 370(72) | 437(83) | 97(20) | 3.3(0.9) | 704(88) |
OR: odds ratio calculated at the 90% cut off point using MaxR; BMI: body mass index; OC: oral contraceptives
a
These women were premenopausal, age 15–49, with no recent miscarriage, pregnancy, within 30 days postpartum or use of depot contraceptives only and were only selected when OC use at the index date was the same as at the time of the blood draw.
b
The OR was calculated at a 75th percentile, since no control individuals were present at a 90th percentile cut-off point