Figure 3.
Morphologic analysis of apoptotic cells during lumen formation. MCF7/CEACAM1-4S cells (2.5 × 105 per well) were grown in Matrigel for 5 (A and B) or 12 (C) days, and transmission electron microscopy was performed. (A) An acinus undergoing apoptosis of the central cell (box). (Magnification, ×5,500.) (B) Nuclear condensation occurring during apoptosis of the central cell seen in A. (Magnification, ×7,375.) (C) An apoptotic body in the lumen of the acinus. (Magnification, ×16,525.) Arrows point to the vacuoles seen in the cytoplasm of the apoptotic cell.