Table 2.
Association between XRCC1 and XPD polymorphisms and breast cancer risk
| Genotype | Cases (%) | Controls (%) | OR (95% CI)a |
| XRCC1-280 | |||
| Arg/Arg | 399 (83.1) | 406 (84.8) | 1.0 |
| Arg/His | 78 (16.3) | 70 (14.6) | |
| His/His | 3 (0.6) | 3 (0.6) | 1.15 (0.80–1.66)b |
| XRCC1-399 | |||
| Arg/Arg | 237 (49.5) | 256 (53.6) | 1.0 |
| Arg/Gln | 196 (40.9) | 185 (38.7) | 1.24 (0.93–1.65) |
| Gln/Gln | 46 (9.6) | 37 (7.7) | 1.39 (0.84–2.29)c |
| Arg/Gln + Gln/Gln | 242 (50.5) | 222 (46.4) | 1.26 (0.96–1.66) |
| XPD-751 | |||
| Lys/Lys | 147 (30.6) | 155 (32.3) | 1.0 |
| Lys/Gln | 238 (49.5) | 237 (49.4) | 1.03 (0.76–1.40) |
| Gln/Gln | 96 (20.0) | 88 (18.3) | 1.10 (0.74–1.63) |
| Lys/Lys+Lys/Gln | 385 (80.0) | 325 (81.7) | 1.0 |
| Gln/Gln | 96 (20.0) | 88 (18.3) | 1.08 (0.77–1.53) |
aOdds ratios (ORs) and confidence intervals (CIs) adjusted for age, age at menarche, age at first full term pregnancy, number of pregnancies, history of benign breast disease, first degree family history of breast cancer, weist-to-hip ratio, smoking and use of alcohol. bOR for Arg/His and His/His genotypes combined. c p for trend = 0.105.