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. 2003 Feb;77(4):2675–2685. doi: 10.1128/JVI.77.4.2675-2685.2003

FIG. 10.

FIG. 10.

Models of how the IE and EICP0 proteins may activate transcription. (A) The IE protein binds to the IE protein-binding consensus 5′-ATCGT-3′ sequence of an EHV-1 promoter and then interacts with the basal transcription factors TFIIB and TBP to trans-activate EHV-1 promoters. (B) The EICP0 protein directly interacts with TFIIB and TBP to trans-activate EHV-1 promoters. (C) The mechanism of the antagonism observed between the IE and EICP0 proteins. Two possibilities were proposed according to our data. First, the IE and EICP0 proteins antagonize by an interaction between the two proteins. Second, the IE and EICP0 proteins antagonize by competing for binding to TFIIB and TBP. The arrows indicate the transcription initiation sites.