Figure 1.

Differential effects of cysteine cathepsin knockouts on angiogenic switching and tumor growth. (A) Angiogenic switching was assessed in RIP1-Tag2 (RT2) mice at 10.5 wk of age by counting the number of angiogenic islets from each individual pancreas and comparing cathepsin knockout RT2 mice to RT2 littermate controls (cathepsin +/+ and +/− littermates) of the same age. (B) The cumulative tumor volume for all tumors in the pancreas was calculated for each RT2 mouse at 13.5 wk of age and grouped by genotype. In both graphs, the means and standard errors are shown, and P values were calculated by comparison to the RT2 littermate control group, using the Wilcoxon t-test; (***) P value of <0.0001; (*) P value of <0.01. The numbers of mice evaluated are indicated below each genotype.