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. 1975 Apr;16(4):277–284. doi: 10.1136/gut.16.4.277

Electrical potential difference, sodium absorption and potassium secretion by the human rectum during carbenoxolone therapy.

A M Tomkins, C J Edmonds
PMCID: PMC1410919  PMID: 1132803

Abstract

The transmucosal electrical potential difference (pd) and the sodium and potassium net fluxes were measured in the rectum of subjects taking carbenoxolone. There was a rise in transmucosal pd persisting throughout treatment in all subjects which was accompanied by an increase in sodium absorption and potassium secretion. Comparison of the pd changes produced by carbenoxolone with those due to the mineralocorticoid 9-alpha-fluorocortisol showed that carbenoxolone had about 1/1000th the potency on a weight basis and the two drugs appeared to be additive in their effects. Topical instillation of carbenoxolone into the rectum produced an elevation of pd which persisted for three days. Amiloride and bendrofluazide did not interfere with these actions of carbenoxolone but spironolactone abolished them. One patient who developed fluid retention and hypokalaemia had a rectal pd similar to that of the other patients who had no side effects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alter S., Cushman P., Hilton J. G. A new guanidine diuretic, amipramizide: reduction of the kaliuretic effect of ethacrynic acid in man. Clin Pharmacol Ther. 1967 Mar-Apr;8(2):243–248. doi: 10.1002/cpt196782243. [DOI] [PubMed] [Google Scholar]
  2. Archampong E. Q., Edmonds C. J. Effect of luminal ions on the transepithelial electrical potential difference of human rectum. Gut. 1972 Jul;13(7):559–565. doi: 10.1136/gut.13.7.559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BORST J. G. G., TEN HOLT S. P., DE VRIES L. A., MOLHUYSEN J. A. Synergistic action of liquorice and cortisone in Addison's and Simmonds's disease. Lancet. 1953 Apr 4;1(6762):657–663. doi: 10.1016/s0140-6736(53)91800-5. [DOI] [PubMed] [Google Scholar]
  4. Beevers D. G. Mineralocorticoids and rectal potential difference. Lancet. 1973 Sep 22;2(7830):682–683. doi: 10.1016/s0140-6736(73)92525-7. [DOI] [PubMed] [Google Scholar]
  5. Braren C. H., Campbell R. G., Hashim S. A., Van Itallie T. B. Use of amiloride in preoperative management of a patient with primary aldosteronism. Am J Med. 1968 Sep;45(3):480–484. doi: 10.1016/0002-9343(68)90082-x. [DOI] [PubMed] [Google Scholar]
  6. COOPERSTEIN I. L., HOGBEN C. A. Ionic transfer across the isolated frog large intestine. J Gen Physiol. 1959 Jan 20;42(3):461–473. doi: 10.1085/jgp.42.3.461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Doll R., Langman M. J., Shawdon H. H. Treatment of gastric ulcer with carbenoxolone: antagonistic effect of spironolactone. Gut. 1968 Feb;9(1):42–45. doi: 10.1136/gut.9.1.42. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Edelman I. S., Fimognari G. M. On the biochemical mechanism of action of aldosterone. Recent Prog Horm Res. 1968;24:1–44. doi: 10.1016/b978-1-4831-9827-9.50007-1. [DOI] [PubMed] [Google Scholar]
  9. Edmonds C. J. Absorption of sodium and water by human rectum measured by a dialysis method. Gut. 1971 May;12(5):356–362. doi: 10.1136/gut.12.5.356. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Edmonds C. J. Effect of aldosterone on mammalian intestine. J Steroid Biochem. 1972 Feb;3(2):143–149. doi: 10.1016/0022-4731(72)90044-1. [DOI] [PubMed] [Google Scholar]
  11. Edmonds C. J., Godfrey R. C. Measurement of electrical potentials of the human rectum and pelvic colon in normal and aldosterone-treated patients. Gut. 1970 Apr;11(4):330–337. doi: 10.1136/gut.11.4.330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Edmonds C. J., Marriott J. C. The effect of aldosterone on the electrical activity of rat colon. J Endocrinol. 1969 Jul;44(3):363–377. doi: 10.1677/joe.0.0440363. [DOI] [PubMed] [Google Scholar]
  13. Edmonds C. J., Richards P. Measurement of rectal electrical potential difference as an instant screening-test for hyperaldosteronism. Lancet. 1970 Sep 26;2(7674):624–627. doi: 10.1016/s0140-6736(70)91397-8. [DOI] [PubMed] [Google Scholar]
  14. Efstratopoulos A. D., Peart W. S., Wilson G. A. The effect of aldosterone on colonic potential difference and renal electrolyte excretion in normal man. Clin Sci Mol Med. 1974 Apr;46(4):489–499. doi: 10.1042/cs0460489. [DOI] [PubMed] [Google Scholar]
  15. LEVITAN R., INGELFINGER F. J. EFFECT OF D-ALDOSTERONE ON SALT AND WATER ABSORPTION FROM THE INTACT HUMAN COLON. J Clin Invest. 1965 May;44:801–808. doi: 10.1172/JCI105192. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Richards P. Clinical investigation of the effects of adrenal corticosteroid excess on the colon. Lancet. 1969 Mar 1;1(7592):437–442. doi: 10.1016/s0140-6736(69)91480-9. [DOI] [PubMed] [Google Scholar]
  17. Shields R., Mulholland A. T., Elmslie R. G. Action of aldosterone upon the intestinal transport of potassium, sodium, and water. Gut. 1966 Dec;7(6):686–696. doi: 10.1136/gut.7.6.686. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. WRONG O., METCALFE-GIBSON A., MORRISON R. B., NG S. T., HOWARD A. V. IN VIVO DIALYSIS OF FAECES AS A METHOD OF STOOL ANALYSIS. I. TECHNIQUE AND RESULTS IN NORMAL SUBJECTS. Clin Sci. 1965 Apr;28:357–375. [PubMed] [Google Scholar]

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