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Vaccination is effective against acute infection. Plaque assays were used to determine the acute viral titers in splenocytes from B6 mice after i.p. challenge with 100 PFU of γHV68. The mean titer was 784 ± 293 PFU for mock-vaccinated mice (n = 8). Titers in vaccinated mice were below the 50-PFU level of detection (n = 8). The difference between mock-vaccinated and vaccinated mice was statistically significant (P = 0.02).
