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. 2003 Feb;77(4):2768–2774. doi: 10.1128/JVI.77.4.2768-2774.2003

FIG. 5.

FIG. 5.

AAV-CMV-human factor IX vectors based on AAV1, AAV2, pH221-213-423, pH221-350-423, or pH212-350-423 were purified by CsCl gradient centrifugation and administered intramuscularly to CD4-knockout mice at a dose of 1011 viral genomes per mouse. Blood from mice was drawn at 6 weeks post-vector administration. The expression levels of human factor IX (hFIX) in mouse plasma were measured by ELISA. Each group consists of four mice. AAV1 and AAV2 vectors with the same transgene were used as controls.