Abstract
A controlled trial of carbenoxolone sodium positioned-release capsules (Duogastrone) was carried out on a randomized series of 100 unselected male Service personnel with symptoms of active duodenal ulceration and supporting radiological evidence. Fifty-seven patients completed the trial, 29 in the carbenoxolone group and 28 in the control group. The carbenoxolone group was given capsules containing 50 mg carbenoxolone four times a day for 12 weeks while the controls received a capsule identical in every respect except that it did not contain carbenoxolone. All patients were assessed at fortnightly intervals and had clinical and radiological reassessments three and six months after commencing treatment.
Review at three months and at six months revealed a slight but clinically insignificant trend in favour of the carbenoxolone group.
As a corollary to this controlled trial, those patients (38 in all) who did not have an early remission of symptoms were removed from the trial and placed on capsules known to contain carbenoxolone. Subsequently these patients did not show an advantage for carbenoxolone.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bank S., Marks I. N., Palmer P. E., Groll A., van Eldik E. A trial of carbenoxolone sodium in the treatment of gastric ulceration. S Afr Med J. 1967 Mar 25;41(12):297–300. [PubMed] [Google Scholar]
- Baron J. H., Nabarro J. D., Slater J. D., Tuffley R. Metabolic studies, aldosterone secretion rate, and plasma renin after carbenoxolone sodium. Br Med J. 1969 Jun 28;2(5660):793–795. doi: 10.1136/bmj.2.5660.793. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Craig O., Hunt T., Kimerling J. J., Parke D. V. Carbenoxolone in the treatment of duodenal ulcer. Practitioner. 1967 Jul;199(189):109–111. [PubMed] [Google Scholar]
- DOLL R., HILL I. D., HUTTON C. F. TREATMENT OF GASTRIC ULCER WITH CARBENOXOLONE SODIUM AND OESTROGENS. Gut. 1965 Feb;6:19–24. doi: 10.1136/gut.6.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Forshaw J. Muscle paresis and hypokalemia after treatment with duogastrone. Br Med J. 1969 Jun 14;2(5658):674–674. doi: 10.1136/bmj.2.5658.674. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Horwich L., Galloway R. Treatment of gastric ulceration with carbenoxolone sodium: clinical and radiological evaluation. Br Med J. 1965 Nov 27;2(5473):1274–1277. doi: 10.1136/bmj.2.5473.1274. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Montgomery R. D., Lawrence I. H., Manton D. J., Mendl K., Rowe P. A controlled trial of carbenoxolone sodium capsules in the treatment of duodenal ulcer. Gut. 1968 Dec;9(6):704–706. doi: 10.1136/gut.9.6.704. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Turpie A. G., Thomson T. J. Carbenoxolone sodium in the treatment of gastric ulcer with special reference to side-effects. Gut. 1965 Dec;6(6):591–594. doi: 10.1136/gut.6.6.591. [DOI] [PMC free article] [PubMed] [Google Scholar]